The FA confirmed the Blues pair will not travel with the Three Lions squad to Warsaw for the World Cup 2014 qualifier on TuesdayChelsea duo Frank Lampard and Ryan Bertrand will not take part in England's World Cup 2014 qualifier with Poland because of injury and illness.
The statement read: "Frank Lampard and Ryan Bertrand have been ruled out of England's Fifa World Cup qualifier with Poland.
"Lampard (calf) and Bertrand (illness) did not take part in England's 5-0 win over San Marino, and will not be ready for Tuesday's game."
Manager Roy Hodgson had initially hoped Lampard would recover in time to feature in Warsaw after missing the 5-0 win over San Marino.
Bertrand caused controversy last week with his rebuttle on Twitter to the accusations he had left the England camp due to a sore throat.
The 23-year-old tweeted: "Just to clarify.... Its not a 'sore throat' Im ill. Swollen glands in my neck... And constant headache for 3 days now and freezin cold.
"Do you think a 'sorethroat' could stop me being apart of a match for my club or country #yourf***ingnuts this is what every boy dreams of."
The Stamford Bridge pair will now prepare for Chelsea's difficult trip to Tottenham next Saturday.