The Barcelona man is preferred to Chelsea striker Fernando Torres up front, and will likely be employed in the ‘false 9’ role in attack.
The former Arsenal man will play in a central role and will be flanked by Pedro and David Silva on either wing.
Santi Cazorla has also been named in the starting XI and will begin the match in a midfield trio also featuring Xavi and Xabi Alonso, with Andres Iniesta being forced to settle for a place on the bench after only recently recovering from injury.
There is also an interesting choice from the Spain coach in defence, with Sergio Busquets being drafted in to partner Sergio Ramos in the centre.
This is due to the absence of first-team regulars Carles Puyol and Gerard Pique, who miss the match through injury.
Spain (4-3-3): Casillas; Arbeloa, Ramos, Busquets, Alba; Xavi, Xabi Alonso, Cazorla; Silva, Fabregas, Pedro
Belarus (4-2-3-1): Veremko; Filipenko, Polyakov, Verkhovtov, Martynovich; Dragun, Bressan; Kislyak, Volodko, Hleb; Rodionov.