Marcello Lippi's big spenders have the pick of the matches away to two-time champions Al Ittihad, while Sepahan play host to Al Ahli and Al Hilal go to Ulsan Hyundai
Marcello Lippi's side will make the trip to Saudi Arabia for the first leg on September 19, before hosting the return leg in early October.
Al Ittihad were one of three Saudi Arabian clubs in the draw, with Al Ahli drawn to face Iranian champions Sepahan, while Al Hilal meet Ulsan Hyundai.
Australian outfit Adelaide United will renew their rivalry with Uzbek champions Bunyodkor, who they met in the 2008 semifinals as well as the 2012 group stage.
The winners of the Al Ittihad-Guangzhou and Sepahan-Al Ahli clashes will meet in the semis, while the victors of the Adelaide-Bunyodkor and Ulsan-Al Hilal will meet in the final four, with the side to progress from that half of the draw to host the final on November 9 or 10.
Al Ittihad v Guangzhou Evergrande
Sepahan v Al Ahli
Adelaide United v Bunyodkor
Ulsan Hyundai v Al Hilal