The remaining teams will vie to become the largest footballing continent's top dog and earn an invitation to the Fifa Club World Cup in December, where they would face Chelsea
In West Asia, fans of Saudi Arabian football will have plenty to cheer about as three of their clubs hope to be the first Saudi side to win the trophy since 2005. Al Ahli, Al Ittihad and Al Hilal will all enter the draw.
Iranian outfit Sepahan are also looking to avenge their 2007 loss to Urawa Reds and become the first team from that country to win since PAS Tehran in 1993.
Four different East Asian countries are also represented; Adelaide United will look for their first finals appearance since 2008, while China's Guangzhou Evergrande, managed to Marcello Lippi, South Korea's Ulsan Hyundai, and Uzbekistan's Bunyodkor are still hoping to reach the tournament climax for the first time.
The draw for the quarter-finals will take place on June 14 in Kuala Lumpur, with the first legs taking place on September 19 before the deciders on October 2 and 3.
Asian Champions League Quarter-finalists
Al Ahli (KSA)
Al Ittihad (KSA)
Al Hilal (KSA)
Adelaide United (AUS)
Ulsan Hyundai (KOR)
Guangzhou Evergrande (CHN)