Jurgen Klopp's men ran out 2-0 winners over Bayern Munich in last week's Supercup clash and are 4/7 (1.57) favourites with William Hill to get their league campaign off to a similarly positive start.
Having been appointed as Sami Hyypia's permanent successor over the summer, Roger Schmidt is available at 9/2 (5.50) to inspire his new team to an eye-catching opening win here.
The pair shared a 2-2 draw in their last meeting back in April and you can get odds of 16/5 (4.20) on them playing out another stalemate this time out.
Schmidt arrives at the BayArena with a reputation for attacking football, having lifted the Austrian Bundesliga trophy while in charge of a rampant Red Bull Salzburg team that scored 110 goals in just 36 fixtures last season.
The former Paderborn boss has spoken of his admiration for Dortmund's adventurous style of play since returning to Germany and seems keen to try to emulate the Schwarzgelben's blueprint with his new team.
Early signs have been promising, with 6-1, 5-1 and 6-0 victories in his first three friendlies immediately endearing himself to his new fans, while last Friday's 6-0 DFB-Pokal win and Tuesday's 3-2 Champions League triumph in Copenhagen suggest that entertainment is unlikely to be in short supply in Leverkusen this season.
Despite losing Robert Lewandowski to Bayern this summer, it is likely to be a similar story for Saturday's hosts, with the likes of Henrikh Mkhitaryan, Pierre-Emerick Aubameyang, Marco Reus and new signing Ciro Immobile combining to form a fearsome attacking line-up.
Having run out 4-1 winners in their own cup clash last weekend, Klopp's men should be confident of playing their part in what looks set to be an exciting opening clash here, when odds of 11/8 (2.38) are not to be missed on over 3.5 goals being scored.
That bet would have paid out in eight of Schmidt's 11 games since taking over so far, as well as two of the last three meetings between these opponents.
|Over 3.5 goals for a 1.5pt stake at 11/8 (2.38) with William Hill|
Sign up with William Hill for a £25 free bet
Al Hain-Cole is an experienced tipster and avid follower of European football. He specialises in accumulators and if you would like to read more from Al you can follow him on Twitter here.