Our Spanish expert Phil Kitromilides believes the visitors will struggle and is backing the hosts to continue their strong home record in front of goal
The Italians host the first leg at their cavernous, crumbling cauldron of a ground - the Stadio San Paolo - which is one of the toughest places for any side to visit in this part of the world. Indeed, Napoli have only lost two Serie A matches at home out of their last 29.
Last season, Juventus ran away with the Scudetto but went down 2-0 in Naples - just an indication of the size of the task facing Athletic Bilbao on Tuesday night.
Paddy Power price the Basques at 7/2 (4.50) while Napoli are offered at 3/4 (1.75), and the draw can be backed at 13/5 (3.60).
That Athletic are even in contention for a place in the group stages of the Champions League is down almost solely to their home form last season.
On the road they were patchy, winning just seven of their 19 away matches in La Liga, and having sold their best player in Ander Herrera to Manchester United, overcoming a strong Napoli side in Italy is a big ask.
Rafael Benitez's side have been in strong form in pre-season, beating Greek Side PAOK as well as Barcelona whilst narrowly losing to Ligue 1 champions Paris Saint-Germain.
Napoli have goals in them - from all over the pitch, too - something that is sadly lacking from Athletic's squad with their main striker Aritz Aduriz unproven at European level and new signing Borja Viguera making a massive step up from the Spanish second division.
All this means that backing the hosts in some way makes sense and the price of 5/6 (1.83) for them to score over 1.5 goals looks appealing.
This bet has paid out in eight of their last 11 competitive games at home and with Atheltic only keeping five clean sheets in 21 competitive away fixtures last season, it has an excellent chance of providing us with some profit once again.
|Napoli to score over 1.5 goals at 5/6 (1.83) for a 2.5pt stake with Paddy Power|
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Phil Kitromilides is a sports journalist and TV presenter in Madrid