Last week's 3-0 victory at the Bernabeu means that Los Blancos can head to Germany, a country in which they have traditionally struggled, supremely confident about their chances of progression.
Paddy Power price the Spanish side at 11/10 (2.10) to notch another victory, while Borussia Dortmund can be backed at 5/2 (3.50), with the draw offered at the same price.
Having rested players in the weekend win at Real Sociedad, Carlo Ancelotti is likely to field a strong line-up at Signal Iduna Park, especially as their next Liga fixture is a seemingly straightforward one at home to lowly Almeria.
It has been a long time since Madrid failed to score away from home in the Champions League, over four years to be exact, with the La Liga outfit netting in each one of their last 22 matches on the road in this competition, and there is no reason to feel that that run will come to an end in Dortmund.
The goalscorer market then might be the best option for us and Karim Benzema to net at anytime is offered at the appealing price of 6/4 (2.50).
The Frenchman has a superb record in this tournament having scored 35 times in 60 appearances.
All four of his goals in this season's tournament have come away from home, and with Benzema enjoying his best ever campaign with Los Blancos, backing him to score against a Dortmund defence that has conceded in each of their last seven European games looks like a good bet.
|Karim Benzema to score at 6/4 (2.50) 2.5pt stake with Paddy Power|
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Phil Kitromilides is a sports journalist and TV presenter in Madrid