Los Rojiblancos' fine midweek draw at the Camp Nou has given them hope of progressing to the Champions League semi finals, but came at a cost as top scorer Diego Costa picked up an injury.
He will miss Saturday's game and is likely to be joined on the sidelines by influential Turkish midfielder Arda Turan.
Nevertheless, bet365 make Atleti clear favorites at 1/2 (1.50) while the visitors are offered at 6/1 (7.00) to become the first team to win a league match at the Calderon this season.
Villarreal's form however has been patchy of late and they have not been clicking as regularly up front as they did at the start of the campaign.
With the Yellow Submarine not firing on all cylinders and Atletico missing key attacking players, backing a low scoring game looks wise and under 2.5 goals is offered at 3/4 (1.75).
This looks an excellent selection given it has paid out in four of Atletico's last five matches as well as in five of Villarreal's previous six encounters. The absentees for the hosts should add further weight to this selection and the match looks set to be a close encounter.
|Under 2.5 goals at 3/4 (1.75) for 2.5pts with bet365