The Swans, now under the stewardship of Garry Monk, crashed out of the FA Cup at the hands of Everton at the weekend but will look to put that disappointment behind them when they square up to Rafa Benitez's men here.
Swansea are chalked up at 11/5 (3.20) with bet365 to claim a famous victory at the Liberty Stadium on Thursday while the in-form Italians can be backed at 11/8 (2.38) with the same firm to grab a first-leg lead. The draw is available at 11/5 (3.20) with bet365.
Napoli come into Thursday's tussle having lost just two of their last 16 matches in all competitions, during which time they also qualified for the Coppa Italia final.
Swansea, by contrast, have struggled to find their form this season and have failed to win 12 of their last 16 matches so it looks set to be a stiff test for Monk's men on Thursday night.
Napoli have conceded just once in their last three matches and with the talents of Jose Callejon and Gonzalo Higuain in the visitors' squad, they could well prove to have too much firepower for a Swansea side that have just two clean sheets in their last 16 games in all competitions.
Benitez's men look to be decent value at 21/10 (3.10) with bet365 to lead Thursday's contest at half-time while the 11/4 (3.75) quote on offer from bet365 for the Serie A side to net in both halves is certainly appealing.
Napoli should prove to be too strong for the home side on Thursday and, therefore, punters are advised to play safe and snap up the generous 11/8 (2.38) quote for Benitez's side to claim a crucial first-leg advantage over the Swans.
|Napoli to win at 11/8 (2.38) 2pts stake with bet365
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