The Catalans head into the game on the back of a 6-0 drubbing of Rayo Vallecano - a game which saw a return to both the pitch and the scoresheet for Neymar, who had been injured for a month and was a potential doubt to feature against Manuel Pellegrini's men.
The Blues, similarly, have been embarrassing visitors to the Etihad Stadium this season, pummelling goal after goal past everyone including the likes of Arsenal and Manchester United - although they have been humbled by Bayern Munich and Chelsea.
Unsurprisingly, bet365 have whacked a 14/1 (15.00) tag on the chances of us seeing a goalless stalemate on Tuesday, then, though interestingly the bookmakers are placing lower odds on Barcelona scoring over 2.5 goals (11/4 (3.75)) than City (9/2 (5.50)).
As well as a host of other offers, bet365 are giving punters the chance to bag a risk-free in-play gamble on the game if they plant a bet before everything gets under way. Anyone who does so will then be given an equal-money free bet during the match should they want to potentially make even more money on the clash.
This is in addition to their Euro Soccer Accumulator, in which you can earn up to 100 per cent on the multiple bet front for all midweek Champions League matches. Simply place a pre-match accumulator on any games from the European competitions and bag a bonus for more choices going into your bet.
If you're planning on watching the European tussle, and hoping to make a bit of money on the clash, why not take up one of bet365's offers? With hundreds of markets on the game, there's a lot of choice available, so get stuck in!
|Bag a risk-free in-play punt with bet365 by placing a pre-match bet
Sign up with bet365 for a first deposit bonus of up to £200