Frank de Boer's men were top of the league at Christmas thanks to a run of six consecutive wins and are 8/13 (1.62) favourites with bet365 to extend their streak in this one.
September's shock 4-0 home win over the champions was no doubt the highlight of an otherwise disappointing first half of the season for the Boeren, who are available at 17/4 (5.25) to complete an unlikely double with victory in the capital.
There have been no draws in any of the last five meetings between the sides, but you can get odds of 3/1 (4.00) on them cancelling each other out this time out.
While this derby between Netherlands' two most successful teams may lack the intensity of Ajax-Feyenoord, it has certainly provided some memorable encounters over the years.
With 51 goals scored in the last 12 meetings, games between this pair are usually high-scoring affairs, and this occasion should be little different considering the form both teams were in prior to the break.
Having hit the back of the net at a rate of three goals a game over their last six league fixtures, the champions will be confident of exacting some revenge against Philip Cocu's men, who have conceded 20 times in the 11 games since their 4-0 win in the reverse fixture.
However, the visitors will be in high spirits themselves after hitting five against Utrecht in their previous away game, and have already bolstered their attack in January with the loan signing of Bryan Ruiz from Fulham, who previously hit 35 goals in 65 Eredivisie games for Twente.
Having suffered 6-2 and 3-1 defeats in big games against Vitesse and Feyenoord respectively recently, it would be no surprise if PSV saw plenty of goals in another high-profile clash against de Amsterdammers, meaning odds of 6/4 (2.50) are not be missed on over 3.5 going in on Sunday.
That bet would have paid out in five of the previous six meetings between the sides, as well as three of the visitors' last four league games.
|Over 3.5 goals for a 1pt stake at 6/4 (2.50) with bet365
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Al Hain-Cole is an experienced tipster and avid follower of European football. He specialises in accumulators and if you would like to read more from Al you can follow him on Twitter here.