Despite remaining unbeaten for their first 15 games, Rudi Garcia's men fell six points off the top after the leaders' 4-0 win over Sassuolo on Sunday, but are available at 11/5 (3.20) with William Hill to close the gap with victory in Lombardy.
Having sneaked into the Champions League knockout stages with an edgy 0-0 home draw against Ajax last week, the Rossoneri are 5/4 (2.20) favourites to move into the top eight with a first home win in six competitive matches.
The pair shared a goalless draw in this fixture last season and you can get odds of 23/10 (3.30) on them cancelling each other out once again this time out.
After opening their season with a record-breaking winning streak, some Giallorossi fans may be scratching their heads as to how their team are not sitting pretty at the top of the table as the winter break approaches.
However, there is no mistaking where the visitors have been found wanting recently, with last week's big win over Fiorentina the first time their blunt frontline had scored more than once in seven fixtures.
Having seen their own side score just three times in their last five at San Siro, the home fans will sympathise with their opponents' frustrations, and a high-scoring game seems unlikely this evening even with the expected return of Francesco Totti for the Giallorossi.
A bet on under 2.5 goals would have paid out both in seven of Roma's last eight league games and each of the hosts' last seven on home soil, meaning odds of 8/11 (1.73) are not to be missed on that market paying out when they come face-to-face.
This lack of firepower has seen the guests draw four of their last five games, and with four of Milan's last five home games also resulting in stalemates, it is well worth backing those 23/10 (3.30) odds on the sides cancelling each other out tonight.
|Under 2.5 goals for a 2pt stake at 8/11 (1.73) with William Hill
||Draw for a 1pt stake at 23/10 (3.30) with William Hill
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Al Hain-Cole is an experienced tipster and avid follower of European football. He specialises in accumulators and if you would like to read more from Al you can follow him on Twitter here.