However, la Celeste still have a chance of claiming an automatic place if they beat their neighbours and Ecuador and Chile do not draw their game in Santiago.
It is far from an ideal scenario but all Uruguay can do is win their game and hope, and Coral price the hosts at 21/20 (2.05) to claim all three points.
Argentina, meanwhile, who are assured of top spot regardless of the result are offered at a seemingly generous price of 5/2 (3.50).
Yet Argentina coach Alejandro Sabella is poised to field a line-up devoid of many first-team stars, with Lionel Messi out and Angel di Maria - who captained the side on Friday - allowed to return to Real Madrid.
While it is very much a dead rubber for the visitors, Uruguay have the incentive of knowing that a win would go a long way to them being seeded at the World Cup should they qualify.
Oscar Tabarez's men to win at 21/20 (2.05) appeals, but Luis Suarez to score at any time at evens (2.00) looks superb. The Liverpool striker has seven goals in his last seven home World Cup qualifiers as well as three goals in his last two matches for the Merseysiders.
Against a far from first-choice Argentina, who have conceded in each of their last three qualifiers, he has every chance of finding the back of the net and offering punters the chance to double their money.
|Luis Suarez to score at anytime at evens (2.00) 1.5 points with Coral|
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Phil Kitromilides is a sports journalist and TV Presenter in Madrid