The Argentina international will be missing for a couple of weeks with a muscle problem, giving Celtic more hope of repeating another shock result. Neil Lennon's men can be backed at 8/1 (9.00) with BetVictor to do just that.
Yet even without Messi, Barca remain massive favorites and are offered at 2/5 (1.40) to record their second victory in this season's Champions League.
While the odds on Barca to win the game do not look appealing, the price for both teams to score looks attractive at 20/21 (1.95).
The Catalans have not always looked the most solid at the back and, although Marc Bartra had an excellent game at Almeria on Saturday, he lacks Champions League experience having played just five times in the competition. As a result, the home side could well find they are able to get on the scoresheet.
Last season they scored home and away against Barcelona and the price of 20/21 (1.95) for a repeat of the bet that paid out twice last term looks a great option.
|Both teams to score at 20/21 (1.95) 1.0pts with BetVictor
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Phil Kitromilides is a sports journalist and TV Presenter in Madrid