Indeed, the Swans boast eight Spaniards in their squad as well as a manager who made his name in La Liga, and coming up against one of the country's traditional powerhouses is a nice story for fans and journalists alike.
Yet Valencia are struggling having lost three league matches in a row for the first time in five and a half years, and William Hill price them at 5/6 (1.83) to get off to a winning start in Europe.
Swansea meanwhile are 4/1 (5.00) outsiders for their trip to Mestalla with the draw offered at 5/2 (3.50).
With four points from four league games, Swansea's domestic start has been almost as disappointing as Valencia's but the Welsh side do look to have goals in them and they showed as much on Monday night against early Premier League pace-setters Liverpool.
Michael Laudrup's side have scored in six of the eight competitive games they have played this season and against a Valencia defence which has conceded three goals in each of their last three games, Swansea should get on the scoresheet.
At the other end of the pitch Valencia are much more reliable though. It has been nine months and 12 matches since Los Che failed to score at home.
Therefore the logical bet is both teams to score offered at 4/5 (1.80) which is fractionally bigger than might have been expected and well worth some investment.
|Both teams to score at 4/5 (1.80) 1.0pts with William Hill
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Phil Kitromilides is a sports journalist and TV Presenter in Madrid