Jose Mourinho's return to Stamford Bridge propelled last season's third-place finishers into the favourites to lift the trophy at the end of the season among some bookies, while David Moyes' arrival at Old Trafford has had an adverse effect on the odds with his club.
Both sides have enjoyed a winning start to 2013-14's competitive campaign with two wins apiece - Chelsea's both in the league, while United triumphed in the Community Shield over Wigan before coming out on top in their opening league fixture.
As always with a battle between these two English giants, the stakes are high and both teams will be desperate to get a psychological boost and numerical advantage over their rivals in Monday night's clash.
To celebrate the massive match-up, bet365 are offering a free in-play bet. All punters have to do is place a bet before kick-off then, once the game is under way, place another bet on any in-play market. If your first in-play bet loses, bet365 will refund this stake, up to the same value as your largest pre-match bet - a maximum of £50.
The Red Devils' home advantage ensures that they are favourites with bet365 heading into the tie, with 6/4 (2.5) likely to be appealing to punters whom consider the reigning champions stronger than the Blues.
Chelsea's summer strengthening - which has seen the likes of Victor Moses and Kevin De Bruyne return from excellent loan spells, while Marco van Ginkel and Andre Schurrle are expected to shine this season - has been the envy of United fans. They are yet to see a big signing arrive at Old Trafford and you can get odds of 2/1 (3.0) if you think Mourinho can take all three points from Manchester, while a draw is 12/5 (3.2).
With numerous attacking options available to both teams on Monday, the options are endless on who could score first in the tie.
Frank Lampard has been in fine scoring form this summer and you can plump for him to score first at 8/1 (9.0). A safer option - considering his goalscoring record and with United playing at home - is Robin van Persie, who is 4/1 (5.0) to score first or 21/20 (2.05) to score at any time.
Of course, these are far from the only options available - there are countless markets to dabble in with bet365 on the match.
This free in-play offer with bet365 is available to all punters, whether you're an existing customer or a new face eager to win money while enjoying what looks set to be an enthralling game, so be sure not to miss out on this cracking deal.
|Get a free in-play bet of up to £50 when you place a pre-match bet on Manchester United v Chelsea with bet365