As if the promise of silverware and local bragging rights weren't enough, the winners of this match will be rewarded with a place in next season's Europa League, with neither side having secured continental qualification in Serie A.
The Giallorossi leapfrogged their neighbours into fifth place with a surprise victory over Napoli on the final day of the league season, and are favourites at 13/10 (2.30) with BetVictor to come out on top at the Stadio Olimpico.
However, Vladimir Petkovic's men have won three of their last four matches against their rivals, so will fancy their chances of securing a victory, at odds of 2/1 (3.00).
The previous meeting between the two sides resulted in a draw at the beginning of last month, and you can get odds of 12/5 (3.40) on this one finishing all square after 90 minutes.
Recent derby matches have been feisty affairs, featuring plenty of goals and almost as many red cards, and there is no reason why this trend shouldn't continue on Sunday.
Lazio have certainly found their scoring boots recently, with the return from injury of Miroslav Klose helping them to 11 goals in their last four games, while Roma have scored as often as champions Juventus this season.
A bet on both teams to score would have paid out in each of the last four encounters between the sides, and looks safe at 8/13 (1.62) in this one.
The Biancocelesti’s star man this season has arguably been Hernanes, whose expertise from set pieces has helped him to grab 14 goals from an attacking midfield position.
The Brazil international has hit the back of the net in four of the last six derbies, and is well worth backing at 19/10 (2.90) to score in 90 minutes in Rome.
|Both teams to score at 8/13 (1.62) with Bet Victor
||Hernanes to score anytime at 19/10 (2.90) with Bet Victor
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Al Hain-Cole is a Liverpool fan, experienced tipster and avid follower of European football. He specialises in accumulators and if you would like to read more from Al you can follow him on Twitter here.