This season, Atleti have of course been a permanent fixture at the other end of the table, and despite surrendering the advantage they held over Madrid, Diego Simeone's men still harbour realistic hopes of finishing above their arch rivals.
That would represent a monumental success for Atletico but to have any hope of achieving it they need to beat Jose Mourinho's men on Saturday and Paddy Power price them at 7/4 (2.75) to do so.
Madrid, meanwhile, can be backed at 6/4 (2.50) to continue their dominance with a win, with the drawn offered at 12/5 (3.40).
As ever when two top teams meet, goals at both ends look likely and with Atleti scoring in all but one of their last 23 home league games and Madrid scoring in all but one of their last 21 matches in all competitions, it is understandable to see both teams to score at just 1/2 (1.50).
That price will attract only the most serious of punters, but a much more attractive selection is to back Atletico to open the scoring at evens (2.00).
Diego Simeone's men will be fresher having not endured a draining midweek Champions League encounter like their rivals and will be hugely motivated to get the win which should mean Madrid relinquish their league crown if Barcelona can claim three points earlier in the day.
Furthermore, Atleti having scored first in 14 of their last 16 home league matches, while Madrid have conceded first in four of their last eight games. With Madrid likely to field a weakened line up this bet has a great chance of paying out.
For a value bet back both teams to score in the first half at 9/4 (3.25) which could well see punters enjoy a healthy profit if, as seems likely, goals are conceded at both ends.
|Atletico to score first at evens (2.00) with Paddy Power
||Both teams to score first at 9/4 (3.25) with Paddy Power|
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Phil Kitromilides is a sports anchor working on TV in Madrid. You can also follow Phil on Twitter.