However that is the task facing Tito Vilanova's men as they head to Germany to take on a Bayern Munich side who have already wrapped up the Bundesliga title in record time.
What's more, Jupp Heynckes' side haven't conceded a goal in their last four matches in the knockout stages, keeping clean sheets both home and away against Celtic and Juventus.
Bayern start the match as 6/5 (2.20) favourites to take a first leg advantage to Barcelona next week, with the draw a 5/2 (3.50) shot, while Barcelona start as the 5/2 (3.50) outsiders.
The hosts to win at both half-time and full-time is priced at 13/5 (3.60) with Barcelona available at 5/1 (6.0) to do likewise.
Barcelona have had a tougher time since the group stages compared to Tuesday's hosts, with the Catalan giants needing to come from behind in both ties against AC Milan and Paris Saint-Germain. But with a comfortable lead established in La Liga they will be fully focused on this match and that cannot be taken lightly.
His side may not be favourites for the match but Lionel Messi still heads the first goalscorer market priced at 4/1 (5.0) just ahead of Mario Gomez, who is a 6/1 (7.0) shot to break the deadlock.
Mario Mandzukic is suspended for the hosts so the likes of Thomas Muller (9/1), Franck Ribery (10/1) or Arjen Robben (8/1) could also reward their backers in the first goalscorer market.
The last time these two sides met in a competitive tie it ended 1-1 and that is an outcome than can be backed at 7/1 (8.0) with BetVictor.
Whatever you're backing in this game, don't forget that if there's a red card shown in the match you could get your money back thanks to BetVictor's red card refund.
If a red card is shown at any time during the Bayern Munich v Barcelona or Borussia Dortmund v Real Madrid match, BetVictor will refund losing Correct Score, First/Last Goalscorer & Scorecast bets on that particular match up to a maximum of £50 per person/house.
|MANCHESTER DERBY MONEY BACK SPECIAL
|If a red card is shown any time during the Bayern Munich v Barcelona match, BetVictor will refund losing Correct Score, first and last goalscorer, scorecast and man of the match bets up to a maximum of £/€50 per person/household.|
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Jim Knight is Betting Editor at Goal.com and has been tipping football games since he was old enough to place a bet. He is a Leicester City fan, writer and member of the We Are Going Up Podcast
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