Atletico, meanwhile, very much enjoyed last weekend, selling out the Calderon for the first time this season and thrashing Granada 5-0.
Contrasting fortunes then for two sides who have endured contrasting seasons, with Atelti currently occupying the position of challenger to the "big two" - a title proudly held by Sevilla in the middle of the last decade - while the Andalusians sit down in tenth.
Despite their desperately indifferent season, Paddy Power price Sevilla as the favorites at 11/8 (2.38) while the side from the capital are offered at 15/8 (2.88). A draw between the two is a 12/5 (3.40) shot.
These two sides have already met three times this season with Atletico securing a 4-3 aggregate victory in the Copa del Rey semi-finals as well as a 4-0 league win back in November.
Yet Atleti's away form has not been the best, while Sevilla have been extremely strong at Ramon Sanchez Pizjuan.
Indeed, the Andalusians have won each of their last seven home matches in La Liga, while Atletico have managed just two away wins from their last nine games on the road.
Both teams to score is offered at 4/6 (1.65) and is a price that will only tempt serious punters, but instead consider taking the evens (2.00) for over 2.5 goals to be scored.
This bet has paid out in 11 of Sevilla's 15 home games in the league this season, including each of their last eight home fixtures.
This has also proved the correct selection in each of the three meetings between the two sides this season and looks an excellent bet at a superb price.
For a value bet, try backing a penalty to be scored in the game at 3/1 (4.00) with the three games between the sides this season seeing a remarkable four penalties scored.
|Over 2.5 goals at evens (2.00) with Paddy Power
||Penalty to be scored at 3/1 (4.00) with Paddy Power|
Sign up with Paddy Power for up to £250 in free bets and back Phil's selections for this match
Phil Kitromilides is a sports anchor working on TV in Madrid. You can also follow Phil on Twitter.