With City not in action until 3pm on Saturday, Alex Ferguson's side have the chance to extend that lead to 18 points over their city rivals with victory over the Black Cats, and they can be backed at 8/13 (1.62) with Paddy Power to bag all three points this weekend.
Sunderland come into this match without a win in their last seven league matches and will be desperate to pick up points as they look to avoid being drawn into the relegation dogfight as the battle to avoid the drop intensifies further.
Martin O'Neill's men will be hampered by the loss of top scorer Steven Fletcher to injury and the home side are rated as a 9/2 (5.50) chance with Paddy Power to claim a vital victory against the Premier League leaders, while the same firm go 3/1 (4.0) that the match ends in stalemate.
United have the best away record in the Premier League this term, having lost just two of their 14 away matches thus far and, with 30 away goals scored so far this season, the Red Devils are the Premier League's top scorers on the road while strike duo Wayne Rooney and Robin van Persie were both on target for their respective nations on international duty in midweek.
With that in mind, Paddy Power's 17/10 (2.70) quote for the Red Devils to win (-1) in the handicap market offers considerable appeal while the generous 6/4 (2.50) quote for Sir Alex Ferguson's side to net in both halves looks to be a solid selection.
United have kept a clean sheet in their last three Premier League matches and can be backed to do so again here, with Steven Fletcher's absence likely to be keenly felt by the Black Cats and, therefore, Paddy Power's 5/4 (2.25) quote for Sunderland to fail to score looks like decent value.
The correct score market will tempt those seeking bigger prices and the value selection is the juicy 13/2 (7.50) quote from Paddy Power for Manchester United to cruise to a 2-0 win over Sunderland on Saturday.
Manchester United to score in both halves at 6/4 (2.50) with Paddy Power
|Manchester United to win 2-0 at 13/2 (7.50) with Paddy Power
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Willie Duncan is a freelance sports journalist. Willie, from Edinburgh, has covered Scottish football for over 10 years and he specialises in football betting markets from across Europe. You can also follow Willie on Twitter