The team from Pamplona, meanwhile, are rock bottom of the Liga table and surely will be more focused on survival than turning around a two-goal deficit.
It is likely then that we will see both coaches make plenty of changes to their sides, with William Hill pricing a home win at 1/2 (1.50) while Osasuna can be backed at 6/1 (7.00) and the draw offered at 3/1 (4.00).
Yet given the slightly sterile nature of the second leg and the fact that the match is not of pressing importance to either side, backing under 2.5 goals at 10/11 (1.91) looks to be a great option.
This was the tip for the first leg and it comfortably paid out while this has also proved to be the correct selection in eight of the last nine competitive matches that Osasuna have played.
For a value bet try backing a goal-less first half at 21/10 (3.10), with this bet paying out in seven of Osasuna's last nine fixtures in all competitions.
This bet also paid in the two previous meetings between the sides this season, which Valencia won 1-0 and 2-0 respectively, with all the goals coming in the second half.
|Under 2.5 goals at 10/11 (1.91) with William Hill
||Under 0.5 goals first half at 21/10 (3.10) with William Hill|
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Phil Kitromilides is a sports broadcaster working on radio and TV in London and Madrid. You can also follow Phil on Twitter.