David Moyes' Premier League high-fliers take on League Two opposition as the overwhelming favourites priced at 1/3 (1.33) for victory with bet365.
While those odds appear bankable considering the gulf in quality between the two squads, the chance of an upset against a visitors team set for rotation does represent a risk.
A draw - available at 9/2 (5.5) - is a real possibility given Everton's main intention this season is to sneak into the Champions League places.
Moyes admitted as much in the build up to the match, saying: "The big money-spinner is the cheque you get from Sky for being in the Premier League."
The Scot still remembers cup losses to minnows Shrewsbury Town and Oldham in the past, but his team may not be up for the occasion at Whaddon Road and a shocking home victory can be backed at 9/1 (10.0).
However, with the most likely outcome being a short odds-on away win, the best main bet for this match appears to be both sides to score at 10/11 (1.90).
That is a healthy price for a potentially weakened Everton side set to face Cheltenham, while staggering this bet would have come in during the Merseyside club's last 17 matches.
The Robins last home game saw them crush Wycombe Wanderers 4-0, and five of their last seven matches have seen the net bulge for both teams.
One young Toffee who could benefit from Moyes shuffling his pack is 19-year-old forward Ross Barkley.
Barkley was recalled from a loan spell at Sheffield Wednesday at the beginning of last December, and made substitute appearances against Stoke and Chelsea to add to his cameo against Leyton Orient in the Capital One Cup back in August.
Four goals from 13 games for Wednesday will have caught the attention of his parent club, and with comparisons being inevitably made with Wayne Rooney, Barkley could really make a name for himself with an FA Cup goal at 3/1 (4.0) anytime.
The local lad has been tipped as a future England player and could even break the deadlock at 11/1 (12.0).
|Both teams to score at 10/11 (1.90) with Bet365
||Ross Barkley to score anytime at 4/1 (4.0) with Bet365|
Jamie Dickenson is a 22-year-old freelance journalist who specialises in football, sports and betting.
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