There are more than just bragging rights at stake for Dave Jones's men though, as they currently find themselves languishing in the relegation zone with just eight points from 10 games.
The hosts have now gone seven games without a league win, so will be desperate to pick up all three points on Friday night, at odds of 67/50 (2.34) with Marathon Bet.
These two sides have not played out a draw in 10 competitive encounters, but you can get odds of 51/20 (3.55) on them cancelling each other out this time.
Unlike their opponents, Leeds come into this game in fine form, and are sure to be suitably fired up for their trip to Hillsborough by former Sheffield United boss Neil Warnock.
The controversial manager knows exactly what it takes to thrive in this division, and has made an encouraging start to his first full season in charge of United by guiding them to the brink of the play-off places.
The Whites have won four of their last five matches in all competitions, and with the in-form partnership of Luciano Becchio and El-Hadji Diouf up front, they are more than capable of subjecting Wednesday to their fourth consecutive home defeat.
Odds of 43/20 (3.15) seem rather generous for a Leeds win here, and are well worth a punt in view of the two sides' respective form.
If you are looking for a slightly more cautious bet, then backing over 2.5 goals to be scored has to be the way to go.
This would have paid out in eight of Leeds' 10 league matches this season, including all five away from Elland Road, and would have been equally successful in eight out of 10 involving The Owls.
Considering the statistics, odds of 18/25 (1.72) are not to be missed in what promises to be an entertaining encounter.
|Over 2.5 goals at 18/25 (1.72) with Marathon Bet
||Leeds to win at 43/20 (3.15) with Marathon Bet|
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Al Hain-Cole is a Liverpool fan, experienced tipster and avid follower of European football. He specialises in accumulators and if you would like to read more from Al you can follow him on Twitter here.
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