The Red Devils have been given a less than daunting group with Braga and CFR Cluj their other opponents but they will be determined not to slip up after last season’s struggles, which saw them knocked out at the group stage.
That should focus the mind and Sir Alex Ferguson will surely have his team motivated for this one after resting key personnel in the 4-0 Premier League win over Wigan at the weekend.
Man Utd are 1/3 (1.33) with Paddy Power to pick up three points here and that is the industry-best price available.
Galatasaray are back under the watchful eye of Fatih Terim in his third spell in charge and the experienced coach has already brought the Turkish title back to the club for the first time in four years.
Money has been invested to strengthen the squad for this European campaign and the team is littered with experienced players.
Indeed, the likes of Tomas Ujfalusi, Hamit Altintop, Johan Elmander, Cris, Felipe Melo and Milan Baros should relish this sort of occasion.
Galatasaray are 10/1 (11.00) with Paddy Power to cause a considerable upset and beat United at Old Trafford. The draw is available at 4/1 (5.00).
In the goalscorer markets, Robin van Persie should start and is the favourite to open the scoring at 3/1 (4.00).
The best bet and main goalscoring threat for Galatasaray is new signing from Trabzonspor, Burak Yilmaz.
The 27-year-old striker was the top scorer in Turkey last season with 33 league goals and has kicked off his Galatasaray career with two in his first three games.
Yilmaz is 11/1 (12.00) to get the first goal at Old Trafford on Wednesday.
But Shinji Kagawa might be the better option. The Japan international has a good scoring record and is likely to be positioned in an advanced role.
He is 7/1 (8.00) to get the first goal but with the home side expected to get a few in this one, the industry-best price of 23/10 (3.30) for Kagawa to score and United to win is the value bet here.
The pick of the bets is another industry-best offering from Paddy Power. United will be keen to show there will be no more sloppiness in Europe this season, so expect them to hit Galatasaray early.
Back United at half-time and full-time at 5/6 (1.83) with Paddy Power as the best bet here.
|Man Utd at HT/FT at 5/6 (1.83) with Paddy Power
||Shinji Kagawa to score and United to win at 23/10 (3.30) with Paddy Power|
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Adam Bate is a professional freelance journalist who specialises in football and betting. He is editor of GhostGoal which can be found here - you can also follow Adam on