After reaching the semi-final of the World Cup in 2010, they went one better by getting to the final of last year's Copa America and comfortably beating Paraguay.
La Celeste - ranked by Fifa as the third best team on the planet - are on a 14-match unbeaten run and, despite Russia always being a daunting trip to make, there is good reason to believe that the 19/10 (2.90) offered on a Uruguay win by 188Bet offers considerable value.
During their unbeaten period (which includes their run in the Copa America), Uruguay have visited some extremely tricky places and come away with impressive results.
Their last three friendly matches have all been on the road but the champions of South America won 3-2 in Ukraine as well as defeating Italy 1-0 in Rome.
Though Russia will be hostile, it is nothing that Uruguay will not have encountered before and banking on this confident side is certainly the way forward.
Dick Advocaat's men are currently preparing for Euro 2012, where they will be competing in Group A alongside the Czech Republic, Greece and co-hosts Poland.
For some slightly higher odds, back Uruguay to win the first half at what looks like an unmissable price of 5/2 (3.50). This bet has paid out in five of their last seven matches and offers excellent value for a small investment.
|Uruguay to win at 19/10 (2.90) with 188 Bet
Uruguay to win the first half at 5/2 (3.50) with 188Bet
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Phil Kitromilides is a sports broadcaster working on radio and TV in London and Madrid, you can also follow Phil on Twitter.
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