The city rivals will face off on Monday evening at Etihad Stadium and Roberto Mancini's men are now into 7/4 following Everton's late comeback at Old TraffordWhen Wayne Rooney added Manchester United's fourth goal against Everton, many would have been forgiven for conceding that the title would once again be headed to Old Trafford despite their local rivals' attempts to dethrone the reigning champions.
A late fight back from David Moyes' men including goals from Steven Pienaar and Nikica Jelavic saw the Toffees claim a point in a thrilling 4-4 draw on Sunday afternoon.
Manchester City then dispatched Wolverhampton Wanderers to condemn Terry Connor's men to playing their football in the Championship next season.
That win, combined with United's draw, has seen the gap at the top eroded to three points, with the two clubs scheduled to meet in a vital clash which could well prove the most important Manchester derby in recent memory.
United still lead the way at 4/9 (1.44) with Bet365, unsurprising given their superior league standing but could Sir Alex Ferguson's side be about to surrender the league lead at a time in the season when they are normally so dominant?
Plenty of punters will be keen to back a City side with such an exceptional home record at 7/4 (2.75). Monday's host have drawn just once at home this season, winning the other 16 encounters, scoring an astounding 51 goals in the process and conceding just 10.
They are 11/10 (2.10) favourites while the visitors are priced at 12/5 (3.40), a price which could tempt those who believe City's need for three points could leave them vulnerable.
The last two matches between the two have been filled with goals, United triumphed 3-2 in the FA Cup while City initially held the bragging rights after a 6-1 win in the Premier League which announced their title credentials with much gusto back in October.
Over 2.5 goals in this game currently trades at 7/10 (1.70) with Bet365. Carlos Tevez, who has represented both clubs in recent years and has been in the headlines for the wrong reasons on many occasions this season, is 11/10 (2.10) to score anytime.
Sign up with Bet365 for up to £200 in free bets and back your pick for the Premier League title
Jim Knight is Betting Editor at Goal.com and has been tipping football games since he was old enough to place a bet. He is a Leicester City fan, writer and member of the We Are Going Up Podcast
Follow Jim on