With just five games left including the final domestic meeting between the top two sides this season, Phil Kitromilides assesses the race to be crowned champions of Spain
Victory for Los Blancos would see them take a virtually unassailable lead with just four matches remaining, while a win for Barcelona would ensure the tiniest of gaps between the two sides.
Currently Madrid retain their status as favourites with Bet365 pricing them at 4/11 (1.36) to be crowned champions, while Barcelona are available at 2/1 (3.00) to retain their title.
However, the Catalans have won 10 of the last 14 Clasicos and should they continue that successful run on Saturday, the odds on them to win the title for a fourth year running would tumble further. Plenty of punters will be keen to get with Pep Guardiola's side ahead of that match at 2/1 (3.00).
Looking at the fixtures which remain for the two sides could be crucial, and Madrid seem to have the tougher run-in. Barca's trickiest remaining match is at home against Champions League chasing Malaga, while Madrid have an imposing visit to the Basque Country to face Athletic Bilbao.
Also worth considering are there respective European committments of the two sides, with Barcelona, who are set to face Chelsea in London on Wednesday in the first leg of the Champions League semi-final and Madrid in Germany 24 hours earlier to face Bayern Munich at the Allianz Arena.
Barcelona remain favourties to win the tournament at 5/6 (1.83) while Madrid can be backed at an industry best 5/2 (3.50) for victory.
The extra day's rest for Jose Mourinho's men may possibly give them a theoretical advantage, and given their recent record in Clasicos, the will side from the capital will take all the help they can get.
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Phil Kitromilides is a sports broadcaster working on radio and TV in London and Madrid, you can also follow Phil on Twitter