The European and world champions play their first match on home soil since leaving for their successful conquest of South Africa. At a tiny 1.05 La Furia Roja are hotter favourites than their famous red shirts to win.
Little value in backing the holders to beat Lithuania. Barring a miracle that's a given. Spain were given a wake up call by Argentina in their last international match being thumped 4-1 by the South Americans.
Goal.com's Spanish betting expert Ivar Matusevich believes that performance was a blip and normal service will be resumed in Salamanca tonight.
"Clearly the result was a shock but the punishment we received in Argentina will knock any complacency out of the Spanish team. Lithuania aren't approaching the level of Argentina and our record in competitive games is incredible.
"Put simply I would expect a routine Spanish win. David Villa is out to beat Raul's goal record and I would fancy him to score in a 3-0 win."
David Villa is a short 1.30 to find the net during the 90 minutes but a much more inviting 2.75 to open the scoring with Sportingbet.
If you fancy our Spanish expert's prediction of a 3-0 home win that is checking out at 5.50.
Spain's last home match was a 6-0 drubbing of Poland before the World Cup. As they are a thin 1.05 to win handicapping looks the way to go if you're having a bet on the game.
* Spain (-2.5 handicap) @ 2.10 (Pinnacle Sports)
* Odds on Spain 6-0 win @ 23.0 (Sportingbet)
* Match Odds: Spain 1.05, Draw 9.50, Lithuania 23.0 (Sportingbet)