The Arsenal forward starts against the Danes to round off his first century of appearances for die Mannschaft, while Boateng's suspension forces Low into a rethink at the back
Coach Joachim Low has handed the Arsenal attacker his third consecutive start of the tournament, despite his relatively subdued performances in the group games against Portugal and Netherlands.
Lars Bender also gets the nod ahead of Benedikt Howedes at right back, with regular incumbent Jerome Boateng missing out through suspension after picking up two yellow cards.
Meanwhile, veteran midfielder Dennis Rommedahl has been ruled out for Denmark after failing to recover from a suspected hamstring injury picked up in the narrow defeat against Portugal on Wednesday.
The Brondby winger has been replaced in the starting XI by 28-year-old Jakob Poulsen, who made his first appearance of the tournament as a substitute against the Seleccao.
Denmark (4-2-3-1): Andersen; Jacobsen, Kjaer, Agger, S. Poulsen; Kvist, Zimling; J. Poulsen, Eriksen, Krohn-Dehli; Bendtner.
Germany (4-2-3-1): Neuer; Bender, Hummels, Badstuber, Lahm; Khedira, Schweinsteiger; Muller, Ozil, Podolski; Gomez.