The West Brom forward is likely to feature in a wide role in place of Kevin Doyle as Giovanni Trapattoni contemplates a switch to a five-man midfield, the Daily Mail claims.
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Spain are likely to pack the midfield and even opted to select Cesc Fabregas ahead of a recognised striker in their opening game against Italy.
It is claimed that Doyle, and not captain Robbie Keane, will be sacrificed to make way for Cox. Aiden McGeady has been adjusting to a more central role during training, with former Swindon star Cox expected to interchange with Keane in a position between the midfield and attack.
Strikers Shane Long and Jonathan Walters, as well as exciting winger James McClean, were also available to Trapattoni but Cox featured as a substitute against Croatia and has been tipped to once again get the nod.
Keane, meanwhile, was reportedly forced to plead with Trapattoni for a place in the team as he endures his worst goal-scoring run for the national team in 11 years.