The 23-year-old forward starts alongside former Valencia colleague David Villa, while Barcelona's Sergio Busquets begins in defence and Andres Iniesta returns for La Roja
Del Bosque has left out Javi Martinez after the Athletic Bilbao midfielder failed to convince in the 3-2 win over Chile on Friday, with Barcelona's Sergio Busquets dropping back to partner Real Madrid's Raul Albiol.
In midfield, Madrid's Xabi Alonso starts alongside Barca duo Xavi and Andres Iniesta. Friday's two-goal hero Cesc Fabregas is on the bench.
Up front, there's a surprise start for Chelsea's Juan Mata, but his club colleague Fernando Torres isn't even on the bench. Barca's David Villa and Sevilla's Alvaro Negredo make up a strong Spanish line-up.
Spain (4-3-3): Casillas; Ramos, Busquets, Albiol, Arbeloa; Xabi Alonso, Xavi, Iniesta; Mata, Villa, Negredo.
Subs: Valdes, Dominguez, Fabregas, Thiago, Pedro, Llorente.
Liechtenstein (4-2-3-1): Jehle; Michael Stocklasa, Rechsteiner, Martin Stocklasa, Beck; Frick, Burgmeier; Buchel, Hasler, Wieser; Ritzberger.
Subs (from): M. Cristen, Hanselman, Kieber, Polverino, Bicer, Eberle, Oehri, A. Cristen, Kaufman, Hasler, B. Buchel.
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