The Germany Under-21 skipper is hoping his side can get their European Championship campaign under way with a win against their rivals
The two countries have shared a fierce rivalry for years and the Tottenham midfielder is determined to start off the tournament with a win.
"There's nothing more pleasant than beating Netherlands," Holtby told Kicker.
"To start off the tournament against our arch rivals is just fantastic. I want to lead the team to the title."
Holtby went on to say that he was determined to put Tottenham's failure to secure a Champions League spot behind him ahead of the tournament.
"That was a catastrophe for us. However, I can't let this bad mood affect die Mannschaft."
Holtby joined the Spurs from Schalke in the winter transfer window for a fee in the region of €1.7 million.