Uruguay a deserved win in a tempestuous game in Montevideo and put a serious dent in Colombia's qualifying hopes in the process. The Celeste have now leapfrogged Colombia into sixth place in the qualifying group and have given themselves real hope of qualifying for the World Cup in South Africa.
Both sides had a man sent off either side of half-time and Uruguay had three more players booked in what was a tense affair.
The hosts took an early lead thanks to a goal after six minutes Ajax striker Luis Suarez as Colombia were still getting to grips with the game.
Then Uruguay defender Carlos Valdes, who started in place of Diego Perez, was the first to receive his marching orders after half an hour.
Colombia didn't enjoy their man advantage for long however as Teófilo Gutiérrez was sent for an early bath immediately after the restart.
The visitors knew they needed a win to give themselves hope of automatic qualification and coach Eduardo Lara made a double substitution just before the hour introducing Giovanni Hernández and Jackson Arley Martinez in place of Giovanni Moreno and Jhon Eduis Viáfara.
It proved an inspired substitution as moments late Jackson Martinez equalised for Colombia, who were aiming to overtake Argentina an Ecuador in the qualifying group with victory tonight.
It was to be a night for inspired substitution as first half sub Andrés Scotti fired Uruguay back in front after 76 minutes and Oscar Tabarez made a double substitution of his own with ten minutes on the clock.
Cristian Rodríguez and Adrian Ramos made way for Dorlan Pabón and Sebastián Eguren and it was Eguren who guaranteed victory with a goal three minutes from time.
The win puts two-time World Cup winners Uruguay right back in contention while Colombia must beat Chile and Paraguay in their remaining games and hope other results go in their favour if they are to have any chance of qualifying.
Paul Madden, Goal.com