The Blues wasted no time in withdrawing the former Barcelona man, who was replaced by Oscar at St Mary's.
Chelsea boss Guus Hiddink had selected the same starting XI for the third consecutive game, with Oscar on the bench and Pedro, Eden Hazard and Willian in the team.
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But the Dutchman could now be without the Spain international for the clash with Norwich City at Carrow Road on March 1.
Pedro joined Chelsea in August and has made 29 appearances since moving to England.