Chelsea lost the former Barcelona man after just seven minutes of the game against Southampton at St Mary's with what appeared to be a hamstring problem
The Blues wasted no time in withdrawing the former Barcelona man, who was replaced by Oscar at St Mary's.
Chelsea boss Guus Hiddink had selected the same starting XI for the third consecutive game, with Oscar on the bench and Pedro, Eden Hazard and Willian in the team.
READ MORE | Conte close to signing Chelsea deal
But the Dutchman could now be without the Spain international for the clash with Norwich City at Carrow Road on March 1.
Pedro joined Chelsea in August and has made 29 appearances since moving to England.