From the dramatic 2008 final in Moscow to a controversial defeat at Anfield, our top memorable matches involving Premier League clubs squaring off in Europe's elite competition
Manchester United, Liverpool, Chelsea and Arsenal have all reached the latter stages of the competition on several occasions, which has often led to all-English ties.
From Chelsea's last-gasp winner at Highbury in 2004 to the west London club's incredible 4-4 draw with Liverpool, all the way to the dramatic scenes in Moscow in 2008 when Manchester United lifted the European Cup after John Terry's penalty miss, there has been drama aplenty in European battles between English clubs.
Ahead of the quarter-final between Chelsea and Manchester United, Goal.com UK takes a look back at the five most exciting all-English clashes in the Champions League...
May 21, 2008: Manchester United 1-1 Chelsea (Man Utd win 6-5 on pens)
Manchester United lifted the Champions League trophy by defeating Chelsea 6-5 on penalties after the teams battled to a 1-1 draw in 120 dramatic minutes.
Sir Alex Ferguson's side took the lead thanks to Cristiano Ronaldo's first-half header but they were pegged back by Frank Lampard's equaliser.
With the teams locked at 1-1 at the break the final was finely poised and Chelsea looked the far likelier of the two English clubs with Lampard and Didier Drogba striking the woodwork, but United held on for extra-time.
The tie then turned in favour of Ferguson's side when Drogba was sent off for a slap on Nemanja Vidic in extra-time, but the sides could not be seperated and the 2008 Champions League would be decided by spot-kicks.
Ronaldo was the first to miss as Chelsea took the upper hand, but the shoot-out turned on its head when John Terry missed by a matter of inches, a penalty which would have given Chelsea their first ever European Cup.
Edwin van der Sar then became the hero as he saved Nicolas Anelka's spot-kick to win United their third European Cup.
|April 14, 2009: Chelsea 4-4 Liverpool
Chelsea advanced to the semi-finals of the Champions league thanks to a 7-5 win on aggregate but they suffered a huge scare during this epic quarter-final.
The Blues led the tie 3-1 after an impressive victory at Anfield but it was Liverpool who took control of the second leg early after a Petr Cech blunder for Fabio Aurellio's free-kick gifted the visitors the lead.
Xabi Alonso then doubled the advantage with a penalty to send the aggregate scores level.
Chelsea did not fold and hit back after Pepe Reina fumbled Didier Drogba's goal-bound flick into the net and then defender Alex hit a thunderbolt free-kick to level the scores on the night and restore their two-goal advantage from the first leg.
Guus Hiddink's side then took the lead through Frank Lampard and the tie looked won. Liverpool were not finished yet though and they fought back to take the lead thanks to goals from Lucas Leiva and Dirk Kuyt.
The Reds were now just one goal away from a memorable away goals victory and a semi-final place with seven minutes of the match remaining.
But it was Chelsea who got the last goal after Lampard fired home to seal a 4-4 draw and with it a semi-final against Barcelona.
|April 6, 2004: Arsenal 1-2 Chelsea
Chelsea stormed into the Champions League semi-final thanks to a late goal from unlikely source Wayne Bridge at Highbury.
After a 1-1 draw in the first leg at Stamford Bridge, Arsenal took the lead just before the interval through Jose Antonio Reyes.
Chelsea showed their fighting qualities after the break and equalised through Frank Lampard after Jens Lehmann spilled Claude Makelele's powerful shot.
The two sides were dead-locked after 177 minutes until Bridge found himself in space inside the Gunners penalty area before rifling a shot past the on-rushing Lehmann.
It gave the Blues a 2-1 win on the night and 3-2 aggregate victory over their London rivals.
|May 5, 2009: Arsenal 1-3 Manchester United
Arsenal's hopes of lifting their first European Cup were blown away by a brilliant display from Manchester United, who sealed a place in their second straight Champions League final.
Arsene Wenger's side were on the end of United's fast start at the Emirates and they struck twice in the opening 11 minutes to give the home side a mountain to climb.
Ji-Sung Park jumped on an error from young left-back Kieran Gibbs and opened the scoring for his side and then Cristiano Ronaldo doubled the lead with a thunderous free-kick from 40 yards.
The Gunners were shell shocked and their plans were in tatters.
Sir Alex Ferguson's side tortured Arsenal on the break and Ronaldo got his second of the game as he applied the finishing touch to a move which started with an Arsenal corner.
Wenger's men did get a consolation after Cesc Fabregas was floored by Darren Fletcher inside the box. The Scot was shown a red card and was suspended from the final against Barcelona.
Robin van Persie slotted home the spot-kick but it did not cloud the superiority United showed over two legs to seal a 4-1 aggregate win.
|May 3, 2005: Liverpool 1-0 Chelsea
Liverpool and Chelsea are the two English clubs who have met the most regularly in European competition over the last decade.
The 2005 semi-final was a hugely memorable affair, not for the scoreline but because of the tension and electric atmosphere in the ground.
The Liverpool fans were up for the occasion, the Kop's volume was turned up to the maximum and it was one of those truly memorable European nights at Anfield.
The tie was evenly poised heading into the second leg after a 0-0 draw at Stamford Bridge but it was Liverpool who gained an early advantage.
Minutes into the second leg Milan Baros beat Petr Cech to a cross before lifting the ball over the stranded 'keeper, and Luis Garcia was on hand to poke the ball home as William Gallas' attempted to clear.
Despite the goal standing, Chelsea's players contested the decision by saying the ball never crossed the line.
After the game Blues manager Jose Mourinho was also adamant the ball didn't go in, but video evidence was inconclusive.
Liverpool boss Rafael Benitez refused to comment on the decision but it was his side who got the benefit of after a gutsy defensive display saw them reach their first final in Europe's elite competition for 20 years.