Despite goals from Zlatan Ibrahimovic and Adrien Rabiot, PSG were held to a 2-2 draw by the Premier League side at Parc des Princes and saw David Luiz and Blaise Matuidi both pick up bookings that will see them suspended for the return match.
But Blanc revealed in his post-match press conference some more disturbing news for the French champions, as he will also be without two more key midfielders.
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“Verratti and Pastore will be absent for the second leg. They will not play,” he told the press.
PSG are set to be seriously short-handed in midfield as a result, which could prompt Angel Di Maria to play in a deeper role or perhaps even hand former Tottenham man Benjamin Stambouli a berth alongside Thiago Motta and Rabiot.
First, they will negotiate a Ligue 1 match in Guingamp on Saturday.