The Parisiens have already qualified for the last 16 and secured top spot in Group C thanks to strong showings in their previous five matches.
The former France coach intends to rotate his squad and blood young players at the Estadio da Luz, but is hopeful his revamped side can stand up to the test.
"There will be players who will find some game time - it's good for them," Blanc told reporters on Monday. "No French team has won here; this is a great challenge for us."
PSG eased to a 3-0 win over the Lisbon club at the Parc des Princes in October, and Blanc is determined to preserve an unbeaten group stage record.
"It's rare to play such a match with no pressure to win, because we are already qualified and top in the group," the coach added.
"For the young players it is amazing to have such a game, in a magnificent stadium - a place steeped in history - without any pressure.
"But we will not play with youth only, there will be international power. Let me be clear: we do not come here to make up the numbers, but to be competitive.
"We know it will be difficult, but we come here to win."