Andre Villas-Boas' side suffered their worst defeat since 1996 on Sunday as City took their league goal tally to 34, adding to the 11 already scored in Europe.
And Nasri warned Plzen, and other upcoming opponents, that the club will continue to go from strength to strength as they look to compete at home and abroad.
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|18/1||Man City are 18/1 with Coral to beat Viktoria Plzen 5-0 on Wednesday|
"We know that is really important for the knockout stages to be first so we are going to fight until the end even though we have already qualified.
"At home we are one of the best in Europe. It is not just against Tottenham, we had good performances against CSKA [Moscow], Manchester United and Norwich.
"It's really good what we are doing at home, but now we have to copy it away from home."
A 5-2 win over CSKA in matchday four confirmed City's place in the last-16 stage for the first time in their history, and Nasri feels the squad bonding and learning from each other has finally come to the fore.
Nasri continued: "I think we have improved as a team and have more experience in the Champions League.
"The last two years were the first two editions for Manchester City. You cannot buy experience. We are better as a team."