The Premier League champions are in action in Spain while an unchanged Manchester City side take on CSKA Moscow meaning Joe Hart again starts the game on the benchManchester United have left Robin van Persie on the bench for Tuesday's Champions League clash at Real Sociedad, with Chicharito partnering Wayne Rooney up front.
David Moyes makes several changes from the side that beat Fulham 3-1 at the weekend with Marouane Fellaini, Ryan Giggs and Shinji Kagawa all coming in while youngster Adnan Januzaj drops out.
In defence, Chris Smalling starts at right-back in place of the injured Rafael while Rio Ferdinand returns to partner Nemanja Vidic at centre-back.
Manchester City are also in action as they take on CSKA Moscow at the Etihad Stadium. Manuel Pellegrini has named an unchanged side from the team that beat Norwich 7-0 on Saturday with Joe Hart again on the bench.
Manchester United starting XI: De Gea; Smalling, Ferdinand, Vidic, Evra; Valencia, Fellaini, Giggs, Kagawa; Rooney, Hernandez.
Subs: Lindegaard, Büttner, Jones, Anderson, Nani, Young, van Persie.
Real Sociedad starting XI: Bravo; C. Martínez, Mikel, Inigo, De la Bella; M. Bergara, Pardo, Zurutuza; Vela, Agirretxe, Griezmann.
Subs: Zubikarai, Ansotegi, Cadamuro, Elustondo, X.Prieto, Chory Castro, Seferovi
Manchester City starting XI: Pantilimon; Zabaleta, Demichelis, Nastasic, Clichy; Nasri, Fernandinho, Toure, Silva; Aguero, Negredo.
Subs: Hart, Richards, Lescott, Kolarov, Milner, Navas, Dzek
CSKA Moscow starting XI: Akinfeev, Ignashevich, A. Berezutski, Nababkin, Schennikov, Wernbloom, Honda, Tosic, G. Milanov, Musa, Doumbia.
Subs: Chepchugov, Vasin, Zuber, Elm, Rahimić, Vitinho, Bazelyuk