Manchester United manager Sir Alex Ferguson has taken the unusual step of starting with Michael Carrick at centre-back for his side's clash with Braga.
Alexander Buttner starts at left-back for the Red Devils in place of Patrice Evra, who is rested alongside veteran defender Rio Ferdinand.
Javier Hernandez and Shinji Kagawa are handed starts in attack whilst Tom Cleverley and Darren Fletcher will form a partnership in central midfield.
Wayne Rooney has been named captain for the match, which sees Ashley Young named on the bench as he steps up his return from injury.
Braga have started with Ruben Micael and Ruben Amorim in support of striker Eder, with Helder Barbosa and Marcio Mossoro dropped after the weekend victory over Guimaraes.
Manchester United starting XI: De Gea; Rafael, Evans, Carrick, Buttner; Fletcher, Kagawa, Cleverley; Hernandez, Van Persie, Rooney.
Subs: Johnstone, Ferdinand, Anderson, Giggs, Nani, Young, Welbeck.
Braga starting XI: Beto; Salino, Nuno Coelho, Vinicius, Elderson; Custodio, Viana; Amorim, Alan, Micael; Eder.
Subs: Quim, Mossoro, Helder Barbosa, da Solva, Baiano, Ze Luis, Anibal.