The Netherlands international starts his first European game for the Rossoneri, whilst Giampaolo Pazzini begins up front on his own
AC Milan will begin their 2012/13 Champions League campaign with Giampaolo Pazzini up front on his won against Anderlecht.
The former Inter man will lead the line against the Belgian champions, being supported by Urby Emanuelson and Kevin-Prince Boateng.
New signing Nigel de Jong will start in a midfield three alongside Antonio Nocerino and Mathieu Flamini.
At the back, youngster Mattia De Sciglio will play at right-back, with Philippe Mexes and Daniele Bonera at centre-back. Luca Antonini starts on the left-side of defence.
For Anderlecht, they have gone with a 4-3-1-2 formation, led by Massimo Bruno and Dieudonne Mbokani.
Kanu supports the two forwards, playing the trequarista role in front of Lucas Biglia, Sacha Kljestan and Guillaume Gillet.
The back four consists of Olivier Deschacht, Bram Nuytinck, Cheikhou Kouyate and Marlin Wasilewski.
Milan (4-3-2-1): Abbiati; De Sciglio, Mexes, Bonera, Antonini; Nocerino, De Jong, Flamini; Boateng, Emanuelson; Pazzini
Anderlecht (4-3-1-2): Proto; Deschacht, Nuytinck, Kouyate, Wasilewski; Biglia, Klejstan, Gillet; Kanu; Mbokani, Bruno