Gunners boss states that he only has two midfielders so could be forced into alterations, and is tempted to start Alex Oxlade-Chamberlain but is unsure if Tomas Rosicky will play
The Gunners will need at least four goals to beat the Italian club - either by taking the game to extra time or beating them outright by five goals.
And Wenger has stated that he may have to go for broke on the night with injuries to several midfielders, and even said he was thinking of playing Alex Oxlade-Chamberlain in a central role.
"I am tempted," Wenger told the club's official website. "At the moment, basically I have only two midfielders, [Alex] Song and [Tomas] Rosicky.
"That means we have to play with four strikers. We can play any system you can imagine until tomorrow night. But I will not tell you that now.
"I am tempted [to play Oxlade-Chamberlain centrally], we will see. I have [around] 24 hours and I have to see if Rosicky is available or not.
"If he is not available then I will be in a very difficult situation, because I don't know what I can do then.
"I hope he will make it. He told me yesterday [Sunday] that he will. But the medical staff are not sure.
"I can play six strikers if I want, I have enough. I have [Marouane] Chamakh, [Chu-Young] Park, [Robin] Van Persie, Gervinho, [Theo] Walcott and Oxlade-Chamberlain. I can take a risk, because I have no choice, basically."