Plzen lost 2-0 to Pep Guardiola's men at Camp Nou a fortnight ago, but Vrba feels his side can make home advantage count as he targets a draw.
"What would be a good result for us? We want to get at least a point. We have a good home record. We want to win at home, although we are aware that in this case it will be extremely hard," the coach told the press.
"However, we want to show more than we did in Barcelona where we did not manage a single attempt on goal.
"We must play aggressively, although we cannot play open football against them.
"I would be happy if we reproduced some of the good moments from our recent league matches. We want to please a full house in Prague.
"It will be a very special night for all of us to host such a great team.
"I've showed the players our game in Barcelona and the things we did well, and the those that we could have done better."
Plzen have just one point from three games thus far.
A loss will see hopes of making the next round end, while Barcelona can book their place in the last 16 with a win.
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