The Spaniard believes a victory in the Czech Republic will relieve pressure and guarantee a place in the next round of Europe as he seeks reassurances in his 200th game in charge
Guardiola will be taking his 200th game in charge of Barcelona, and he wants to mark the occasion with a success.
However, he expects the Czech side to put on a hard-fought display on the pitch in Prague.
"A win would mean a place in the round of 16 and we would have nothing to worry about until February," Guardiola told the press.
"It would also mean the pressure would be off when we visit Milan [on matchday five] so we could give some other players a chance to impress and focus for a while on the league and the Copa del Rey."
However, despite his forward vision, Guardiola knows navigating their way past Plzen will likely be tough, despite beating them 2-0 at Camp Nou.
"[Plzen] are a strong, fast team; they defended very well against us [on matchday three].
"It is easier once you have played against each other, but our most important task for tomorrow is to adapt our tactics to how Plzen defend."
Guardiola continued: "I know it will be my 200th match in charge of this great team.
"I did not expect to be Barcelona coach for such a long time.
"Not everything has been perfect during these four years, but we have won lots of trophies together, and that speaks for itself.
"I am proud of the players I have and I think we have achieved good results together.
"They constantly improve and they push me forward as well. They have made me a better coach."
Kick-off is at 20.45CET. Barcelona are level on seven points with AC Milan at the top of Group H.
The Italians take on BATE Borisov in the other group game.
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