The Portuguese tactician acknowledged that United are highly favoured for the match, but noted his own side will the enter the match looking for maximum points
The Portuguese club will take on United in their first match in the group stage after earning a place in the competition via the play-off.
Benfica were happy to learn that the Premier League champions will be without their first-choice central-defensive pairing, as Rio Ferdinand has been rested, while Nemanja Vidic is still recovering from a calf injury.
But Jesus played down that situation, and stated that United still have plenty of quality options at their disposal.
"What matters for this game is knowing that Manchester United are strong in offence and they have creative players," he told reporters at a press conference.
"The fact that this or that player cannot play does not make them weaker.
"Their offensive power, with players like Nani, makes them a balanced team, who are hard to overcome."
The two clubs have faced each other seven times, with Benfica's only victory dating back to 2005 in a 2-1 win which sent United out of the Champions League.
Jesus conceded that the Premier League side are the favourites for Wednesday's tie, but stressed his side will go out for the victory.
"The favouritism belongs to them because of their players and their past," Jesus told reporters at a press conference.
"They are one of the best teams in the world, but that will not inhibit us. We will play the game with the utmost respect, but it seems to me we have ability to surprise United.