The Spain international has been quick to turn the mindset firmly on Europe after the draw with Real Sociedad, as he gives a taste of what to expect against the Italians
Busquets, who featured in the 2-2 draw away to Real Sociedad in La Liga, has tried to alleviate concerns ahead of the European showdown.
But, he knows the Italian champions will arrive in Spain with intent.
"The main danger is Milan's quality. They are a historic club with great players," Busquets is quoted as saying on El Mundo Deportivo.
"They have [Zlatan] Ibrahimovic, [Antonio] Cassano, and Robinho, very dangerous players.
"But, it will be important for us to start with the three points. Milan are a strong rival who will be fighting for the top places in the group.
"We hope to win in front of our fans."
Kick-off at Camp Nou on Tuesday is at 20:45 (CET), but there is news Robinho may not make the game.