It was United's rivals Manchester City who sent Andre Villas-Boas' men to a 6-0 defeat last weekend - their worst result in the Premier League since a 7-1 loss to Newcastle United in December 1996 - destroying the best defensive record in the English top flight in the process.
A Europa League triumph over Tromso did little to distract from Tottenham's domestic struggles, with consecutive defeats compounded by a persistent inability to find the net.
|14/1||Tottenham are 14/1 with BetVictor to beat Man Utd 2-0|
But it is not all doom and gloom at White Hart Lane, with Tottenham still very much in touch with the top four and, despite their Etihad Stadium capitulation, Villas-Boas' charges still boast more clean sheets [seven] than any other team in the division.
Games against United rarely provide cause for cheer among the Tottenham ranks, though - the London club have not enjoyed a victory on home soil over the Old Trafford outfit since 2001.
The opportunity to achieve that feat twice in a calendar year passed them by when, in September of the following season, Spurs threw away a three-goal half-time lead to lose 5-3.
Ryan Giggs is one United player who appears to particularly enjoy games against Tottenham, with the Welshman having scored 10 times in matches with them - more than against any other opponent.
The winger turned 40 on Friday and has his sights set on securing a 14th Premier League winners' medal.
Manager David Moyes has paid tribute to the one-club veteran, who has made 953 club appearances since his debut in 1991.
"To be playing so well at his age is terrific and a great example to young players," the Scot said. "We don't look at his age. We look at his experience. He's the right player for this stage."
Moyes' side have turned a corner after a slow start to the campaign with an 11-game unbeaten run, which includes strong form in the Champions League, lifting their spirits.
The hosts, who made nine changes for Thursday's triumph in Norway, could be without Emmanuel Adebayor [groin], while fellow striker Harry Kane [knee], defender Danny Rose [foot] and midfielder Christian Eriksen [ankle] are all sidelined.
Moyes is hopeful that Dutchman Robin van Persie [groin] and defender Nemanja Vidic [head] will return, but midfielder Michael Carrick [Achilles] will miss out.