Decio de Maria, general secretary of the Mexican Football Federation (Femexfut), has revealed that a total of five players have been provisionally suspended from the team until investigations on the use of banned substance clenbuterol have taken place.
Goalkeeper Guillermo Ochoa, defenders Francisco Rodriguez and Edgar Duenas and midfielders Antonio Naelson and Christian Bermudez have all tested positive for the controlled substance.
The quintet are currently with the Mexican national team for the Concacaf Gold Cup, in which El Tri secured a 5-0 win over El Salvador in their opening match, on Sunday.
Ricardo Osorio has also been suspended, but the defender had already been ruled out of the tournament with urinary tract infection and is currently receiving treatment in his homeland.
Mexico are due to play Cuba tonight and the players in question have already been informed they will not be able to take part in the match.
According to Goal.com U.S. Latino, Mexico can play the remainder of the competition with just 17 players and there is no risk that the result of their first encounter with El Salvador will be overturned.
If the players are proved guilty, they will face bans that could range from six months to two years.
In a press conference, Decio de Maria noted that suspending the players provisionally and separating them from the team was the only thing to do.
"What the federation must do is analyse the case and determine what happened," he added.
"I repeat, there is no responsibility or negligence about this matter, I hope this is an accident and we have to demonstrate it to solve this."