The Blues skipper has failed to recover from an ankle injury sustained against Aston Villa on Saturday, with 203-goal Frank Lampard captaining the side in his absenceJohn Terry will miss his second European final in as many seasons when Chelsea take on Benfica, with Frank Lampard captaining the Blues in his absence.
Terry has failed to recover from an ankle injury picked up during Saturday's 2-1 victory over Aston Villa, while Eden Hazard is also absent with a hamstring problem picked up in the same game.
Lampard will be flanked by Brazilians David Luiz and Ramires in a three-man midfield, with Gary Cahill partnering Branislav Ivanovic at the heart of the defence.
Benfica boss Jorge Jesus has fielded his strongest available line-up, with Nemanja Matic set to face his former club in central midfield.
Benfica: Artur; Almeida, Luisao, Garay, Melgarejo; Perez, Matic, Gaitan, Salvio; Rodrigo, Cardozo.
Subs: Paulo Lopes, Jardel, Andre Gomes, Aimar, Urreta, Ola John.
Chelsea: Cech; Azpilicueta, Ivanovic, Cahill, Cole; Ramires, Lampard, Luiz; Oscar, Mata; Torres.
Subs: Turnbull, Ferreira, Ake, Mikel, Marin, Benayoun, Moses.